Trifluoroacetic acid → N-Azetidin-3-yl-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt

HRID 2089131ノート

反応式

HRID 2089131 の反応式
C(OC([N:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:29])[CH2:14][NH:15][C:16]2[C:20]3[CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=[CH:24][C:19]=3[O:18][N:17]=2)[CH2:9]1)=O)(C)(C)C.[C:30]([OH:36])([C:32]([F:35])([F:34])[F:33])=[O:31]>C(Cl)Cl>[OH:36][C:30]([C:32]([F:35])([F:34])[F:33])=[O:31].[NH:8]1[CH2:11][CH:10]([NH:12][C:13](=[O:29])[CH2:14][NH:15][C:16]2[C:20]3[CH:21]=[C:22]([C:25]([F:26])([F:28])[F:27])[CH:23]=[CH:24][C:19]=3[O:18][N:17]=2)[CH2:9]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 674789043-[2-(5-Trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 86660176N-Azetidin-3-yl-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-[2-(5-Trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester (500 mg, 1.21 mmol) in DCM (5 mL) and TFA (5 mL) was stirred at room temperature for 1 hour. The solvent was removed and then lyophilized overnight to give the title compound as colorless oil.

後処理

  1. customThe solvent was removed

出典と根拠

ORDレコード
ord-da8966db0cee432a98f071861064bc60
出典データセット
uspto-grants-2013_05
特許番号
US08436023B2

反応ノート

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