5-Fluoro-1-indanone → 5-Fluoro-2,3-dihydro-1H-inden-1-ol
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2.[BH4-].[Na+]>CO>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7]([OH:11])[CH2:6][CH2:5]2参加物
4
実験手順
To a solution of 5-fluoroindanone (CAS#700-84-5, 0.942 g, 6.274 mmol) in methanol (15 mL) at 0° C. is added sodium borohydride (0.356 g, 9.411 mmol) in one portion. The cooling bath is removed and after 2 hours, the mixture is poured into water (100 mL) and the volatile organics are removed in vacuo. Extraction with dichloromethane, drying over magnesium sulfate, filtering through a cotton plug and concentration affords 5-fluoro-indan-1-ol, which is used in the next step without further purification.
後処理
- customThe cooling bath is removed and after 2 hours
- additionthe mixture is poured into water (100 mL)
- customthe volatile organics are removed in vacuo
- extractionExtraction with dichloromethane
- dry with materialdrying over magnesium sulfate
- filtrationfiltering through a cotton plug and concentration
出典と根拠
- ORDレコード
- ord-df36559a14e84ed39e2af6706c18d772
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08436035B2
反応ノート
読み込み中…