Water → 7-pyrrolidin-1-yl-3,4-dihydro-2H-naphthalen-1-ol

HRID 2089475ノート

反応式

HRID 2089475 の反応式
[N:1]1([C:6]2[CH:15]=[C:14]3[C:9]([CH2:10][CH2:11][CH2:12][C:13]3=[O:16])=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[BH4-].[Na+].O>CO>[N:1]1([C:6]2[CH:15]=[C:14]3[C:9]([CH2:10][CH2:11][CH2:12][CH:13]3[OH:16])=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 591994477-pyrrolidin-1-yl-3,4-dihydro-2H-naphthalen-1-one

生成物 1

HCID 675492557-pyrrolidin-1-yl-3,4-dihydro-2H-naphthalen-1-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 7-pyrrolidin-1-yl-3,4-dihydro-2H-naphthalen-1-one (0.548 g, 2.55 mmol) in methanol (20 mL) at 0° C. is added sodium borohydride (0.241 g, 3.54 mmol) and the reaction is stirred for 1.5 hours, whereupon water is added and the volatiles are removed in vacuo. The mixture is extracted with dichloromethane. The organic phase is dried over sodium sulfate, filtered, and concentrated to give 7-pyrrolidin-1-yl-3,4-dihydro-2H-naphthalen-1-ol, which is used in the next step without further purification.

後処理

  1. additionis added
  2. customthe volatiles are removed in vacuo
  3. extractionThe mixture is extracted with dichloromethane
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-099b40a8097e4746a0f7dfce6f449449
出典データセット
uspto-grants-2013_05
特許番号
US08436035B2

反応ノート

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