m-Chloroperbenzoic acid → Methyl thieno[3,4-b]thiophene-2-carboxylate

HRID 2090127ノート

反応式

HRID 2090127 の反応式
[CH3:1][O:2][C:3]([C:5]1[S:9][C:8]2[CH2:10][S:11][CH2:12][C:7]=2[CH:6]=1)=[O:4].C1C=C(Cl)C=C(C(OO)=O)C=1>C(OCC)(=O)C.C(=O)=O>[S:9]1[C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][C:7]2=[CH:12][S:11][CH:10]=[C:8]12

参加物

5

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 3441857Methyl 4,6-dihydrothieno[3,4-b]thiophene-2-carboxylate

生成物 1

HCID 19007653Methyl thieno[3,4-b]thiophene-2-carboxylate

試薬・触媒・溶媒 2

HCID 280Carbon Dioxide溶媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

A solution of 2.0 g (10 mmol) (3) in 30 mL ethyl acetate was stirred and cooled down in dry ice bath. MCPBA (1.75 g, 10 mmol) in 30 mL ethyl acetate was added dropwise to the reaction solution. After the addition, the mixture was kept stirring for overnight. Then the solvent was removed by evaporation and the residue contained a crude product of (4) and 3-chlorobenzoic acid.

後処理

  1. additionAfter the addition
  2. customThen the solvent was removed by evaporation

出典と根拠

ORDレコード
ord-d13cef28273b45cbaea9509a10853449
出典データセット
uspto-grants-2013_05
特許番号
US08436134B2

反応ノート

読み込み中…