3-[4-(2-Benzyloxy-acetoxy)-phenyl]-2-{3-[4-(2-benzyloxy-acetoxy)-phenyl]propionyl amino}-propionic acid methyl ester → 3-[4-(2-Hydroxy-acetoxy)-phenyl]-2-{3-[4-(2-hydroxy-acetoxy)-phenyl]-propionylamino}-propionic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:47])[CH:4]([NH:24][C:25](=[O:46])[CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][C:35](=[O:45])[CH2:36][O:37]CC2C=CC=CC=2)=[CH:30][CH:29]=1)[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13](=[O:23])[CH2:14][O:15]CC2C=CC=CC=2)=[CH:8][CH:7]=1>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][C:3](=[O:47])[CH:4]([NH:24][C:25](=[O:46])[CH2:26][CH2:27][C:28]1[CH:29]=[CH:30][C:31]([O:34][C:35](=[O:45])[CH2:36][OH:37])=[CH:32][CH:33]=1)[CH2:5][C:6]1[CH:7]=[CH:8][C:9]([O:12][C:13](=[O:23])[CH2:14][OH:15])=[CH:10][CH:11]=1参加物
4
反応物 1
生成物 1
試薬・触媒・溶媒 2
実験手順
3-[4-(2-Benzyloxy-acetoxy)-phenyl]-2-{3-[4-(2-benzyloxy-acetoxy)-phenyl]propionyl amino}-propionic acid methyl ester 25 (10 grams, 15.64 mmol) is dissolved in ethyl acetate (100 mL) in a pressure vessel, palladium on carbon (10%, 5 grams) is added and the mixture is stirred under an atmosphere of hydrogen (4 Kg) for 5 hours. The catalyst is removed by filtration and is distilled of the ethyl acetate. The crude 26 can be purified in appropriate solvent.