Sodium Hydroxide → HCID 57770667、化合物

HRID 2091823ノート

反応式

HRID 2091823 の反応式
C[O:2][C:3](=[O:26])[C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][N:11]=2)[CH:7]=[C:6]([C:17]2[N:18]([CH2:22][CH:23]3[CH2:25][CH2:24]3)[N:19]=[CH:20][CH:21]=2)[CH:5]=1.[OH-].[Na+]>CO>[CH:23]1([CH2:22][N:18]2[C:17]([C:6]3[CH:5]=[C:4]([CH:9]=[C:8]([C:10]4[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][N:11]=4)[CH:7]=3)[C:3]([OH:26])=[O:2])=[CH:21][CH:20]=[N:19]2)[CH2:25][CH2:24]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 57770606HCID 57770606、化合物

生成物 1

HCID 57770667HCID 57770667、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-(2-Cyclopropylmethyl-2H-pyrazol-3-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester (1.14 g, 3.27 mmol was dissolved in 20 mL MeOH, and 3N aqueous NaOH (3 mL) was added. The reaction mixture was stirred at room temperature for three hours, then concentrated under reduced pressure. The residue was acidified to pH 3 and extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure to give 0.9 g of 3-(2-cyclopropylmethyl-2H-pyrazol-3-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid, MS (M+H)=334.

後処理

  1. concentrationconcentrated under reduced pressure
  2. extractionextracted with EtOAc
  3. dry with materialThe combined organic layers were dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-4ebe2dfed5a1417cb4d39114c2b83188
出典データセット
uspto-grants-2013_05
特許番号
US08440673B2

反応ノート

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