Ammonium Chloride → 2-Chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carboxamide

HRID 2091888ノート

反応式

HRID 2091888 の反応式
[Cl:1][C:2]1[N:3]=[C:4]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[C:5]2[N:11]=[C:10]([C:12](O)=[O:13])[CH:9]=[CH:8][C:6]=2[N:7]=1.[Cl-].[NH4+].C[N:24](C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C.O>[Cl:1][C:2]1[N:3]=[C:4]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[C:5]2[N:11]=[C:10]([C:12]([NH2:24])=[O:13])[CH:9]=[CH:8][C:6]=2[N:7]=1

参加物

7

反応物 4

HCID 25517Ammonium ChlorideHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 584050092-Chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carboxylic acid

生成物 1

HCID 584050312-Chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carboxamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

2-Chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carboxylic acid from Example 118 (0.12 g) was reacted with ammonium chloride (7 eq), HATU (1.5 eq) and DIPEA (4 eq) in DMF (5.2 mL) for 30 minutes. The reaction mixture was then diluted with water and the orange solid was collected by filtration to give 90 mg of 2-chloro-4-morpholinopyrido[3,2-d]pyrimidine-6-carboxamide.

後処理

  1. filtrationthe orange solid was collected by filtration

出典と根拠

ORDレコード
ord-0397394dc08945e1ae660420d4dc7aba
出典データセット
uspto-grants-2013_05
特許番号
US08440651B2

反応ノート

読み込み中…