Hydrazine hydrate (1:1) → HCID 55285530、化合物
反応式
[O:1]=[C:2]1[C:7]([CH2:8][N:9]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:6][CH:5]=[N:4][NH:3]1.O.NN>CO>[NH2:9][CH2:8][C:7]1[C:2](=[O:1])[NH:3][N:4]=[CH:5][CH:6]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
2-[(3-Oxo-2,3-dihydropyridazin-4-yl)methyl]isoindoline-1,3-dione (255 mg, 1.00 mmol) in methanol (2 mL) was mixed with hydrazine monohydrate (250 mg, 5.00 mmol) at room temperature and stirred at 60° C. for 3 hours. After completion of the reaction, the solid was filtered off with chloroform, and the filtrate was evaporated under reduced pressure repeatedly to give a crude reaction product containing the desired product, which was used for the next step.
後処理
- customAfter completion of the reaction
- filtrationthe solid was filtered off with chloroform
- customthe filtrate was evaporated under reduced pressure repeatedly
- customto give a crude
- customreaction product
出典と根拠
- ORDレコード
- ord-89079f8daeeb463581cb0b7bed38ea0a
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08440666B2
反応ノート
読み込み中…