Ammonium Chloride → HCID 59574603、化合物
反応式
[Cl:1][C:2]1[C:3]([F:10])=[N:4][CH:5]=[CH:6][C:7]=1[CH:8]=[O:9].[CH3:11][Mg]Br.[Cl-].[NH4+]>O1CCCC1>[Cl:1][C:2]1[C:3]([F:10])=[N:4][CH:5]=[CH:6][C:7]=1[CH:8]([OH:9])[CH3:11]参加物
5
実験手順
3-Chloro-2-fluoropyridine-4-carbaldehyde (56.1 mg, 0.35 mmol) in tetrahydrofuran (2 mL) was mixed with methylmagnesium bromide (0.98 M in tetrahydrofuran, 1.13 mL, 1.05 mmol) under −78° C., and the reaction mixture was warmed slowly to room temperature for 16 hours with stirring. After completion of the reaction, the reaction solution was mixed with saturated aqueous ammonium chloride and extracted with ethyl acetate, and the organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure. The resulting crude reaction product containing the desired product was used for the next step (64.7 mg).
後処理
- customAfter completion of the reaction
- extractionextracted with ethyl acetate
- dry with materialthe organic layer was dried over anhydrous sodium sulfate
- customevaporated under reduced pressure
- customThe resulting crude reaction product
出典と根拠
- ORDレコード
- ord-aa6c34562f314e3dafda66c497b752fa
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08440666B2
反応ノート
読み込み中…