Nitric Acid → 4,5-Dibromo-6-nitropyridazin-3(2H)-one
反応式
[Br:1][C:2]1[C:3](=[O:9])[NH:4][N:5]=[CH:6][C:7]=1[Br:8].[N+:10]([O-])([OH:12])=[O:11]>S(=O)(=O)(O)O>[Br:1][C:2]1[C:3](=[O:9])[NH:4][N:5]=[C:6]([N+:10]([O-:12])=[O:11])[C:7]=1[Br:8]参加物
4
実験手順
To 4,5-dibromopyridazin-3(2H)-one (2 g, 7.87 mmol) in concentrated sulfuric acid (12 mL), fuming nitric acid (978 μL, 23.8 mmol) was gradually added at 100° C. with stirring, and the resulting reaction solution was stirred at 100° C. for 3 hours. After completion of the reaction, the reaction solution was cooled to room temperature and poured onto ice-cold water. The precipitated crystals were collected by filtration and dried under reduced pressure to give the desired product (2.2 g, 93%).
後処理
- customthe resulting reaction solution
- stirringwas stirred at 100° C. for 3 hours
- customAfter completion of the reaction
- additionpoured onto ice-cold water
- filtrationThe precipitated crystals were collected by filtration
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-14c3f33e90d74c61b4f2fb53feed750a
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08440666B2
反応ノート
読み込み中…