Trifluoroacetic acid → 1-Benzyl-1,2,3,4-tetrahydroquinolin-3-amine

HRID 2092170ノート

反応式

HRID 2092170 の反応式
FC(F)(F)C(O)=O.C(OC(=O)[NH:14][CH:15]1[CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:16]1)(C)(C)C.C(=O)([O-])[O-].[K+].[K+]>ClCCl.CO>[CH2:25]([N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:24][CH:15]([NH2:14])[CH2:16]1)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

参加物

6

反応物 3

HCID 6422Trifluoroacetic acidHCID 11430Potassium CarbonateHCID 67236612Tert-butyl 1-benzyl-1,2,3,4-tetrahydroquinolin-3-ylcarbamate

生成物 1

HCID 640312941-Benzyl-1,2,3,4-tetrahydroquinolin-3-amine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (3 mL) was added to a solution of (1-benzyl-1,2,3,4-tetrahydroquinolin-3-yl)-carbamic acid tert-butyl ester (481 mg, 1.42 mmol) in dichloromethane (6 mL), stirred for 30 minutes at ambient temperature, and concentrated. A solution of the resulting oil in methanol (10 mL) was treated with potassium carbonate (393 mg, 2.84 mmol), stirred for an hour at room temperature, and concentrated to afford the title compound as yellow residue. MS (DCI/NH3) m/z: 239.1 [M+H]+.

後処理

  1. concentrationconcentrated
  2. stirringstirred for an hour at room temperature
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-b9b4f76b4c9f4a70ab9327bf1337f1c9
出典データセット
uspto-grants-2013_05
特許番号
US08440691B2

反応ノート

読み込み中…