Nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene → 4-(2,2,2-Trifluoro-1-methyl-ethoxy)-aniline

HRID 2092687

反応式

HRID 2092687 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH:11]([CH3:16])[C:12]([F:15])([F:14])[F:13])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[F:13][C:12]([F:14])([F:15])[CH:11]([CH3:16])[O:10][C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=1

参加物

4

反応物 1

HCID 66577895Nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene

生成物 1

HCID 662775684-(2,2,2-Trifluoro-1-methyl-ethoxy)-aniline収率 98.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene (6.74 g) was dissolved in MeOH (70 mL). Pd on carbon (10% Pd, 500 mg) was added and the mixture was hydrogenated at RT for 12 hours. The suspension was filtered and the filtrate was concentrated in vacuo to provide the title compound as a brown liquid (5.8 g). Rf: 0.38 (silica gel, ether/heptane 1:1). MS (m/e): 206.1 (MH+).

後処理

  1. filtrationThe suspension was filtered
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-2d8ee7dcd7514d0fa0a82721d3c39024
出典データセット
uspto-grants-2013_05
特許番号
US08440710B2

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