関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Malic Acid | HCID 525 | — |
| 反応物 | 5,8,14-Triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene | HCID 170361 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | Varenicline Malate | HCID 86653157 | — |
反応手順
To a solution of Varenicline base (1 g) in 2-propanol (15 mL) at 40° C., malic acid (1.55 g) was added. The resulting suspension was heated at 40° C. for 1 h and allowed to cool to ambient temperature for 5 h. Finally, the solid was filtered and dried at 40° C. under vacuum. HPLC purity: 99.70%; XRD Analysis: Form III.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08440825B2 |
|---|
| 出典データセット | uspto-grants-2013_05 |
|---|
| ORD ID | ord-67b8cddde33346588060f63ce2bb82e7 |
|---|
| 出典メモ | uspto-grants-2013_05 |
|---|
