反应详情

温度

40 °C

To a solution of Varenicline base (1 g) in 2-propanol (15 mL) at 40° C., malic acid (1.55 g) was added. The resulting suspension was heated at 40° C. for 1 h and allowed to cool to ambient temperature for 5 h. Finally, the solid was filtered and dried at 40° C. under vacuum. HPLC purity: 99.70%; XRD Analysis: Form III.

1. temperatureto cool to ambient temperature for 5 h
2. filtrationFinally, the solid was filtered
3. customdried at 40° C. under vacuum