Ethyl bromoacetate → Ethyl 2-(1,3-benzodioxol-5-ylamino)acetate
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[O:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[CH3:17][CH2:18][O:19][C:20]([CH2:22]Br)=[O:21]>CN(C=O)C>[CH2:18]([O:19][C:20](=[O:21])[CH2:22][NH:10][C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH2:2][O:3][C:4]=2[CH:9]=1)[CH3:17]参加物
5
実験手順
To a solution of Benzo[1,3]dioxol-5-ylamine (1.2 eq.) and potassium carbonate (2.2 eq.) in DMF at 0° C. was added ethyl bromo acetate and stirred at room temperature for overnight. Reaction was then quenched with water and extracted with ethyl acetate, dried over sodium sulphate and concentrated under reduced pressure to afford crude product, which, on purification by column chromatography afforded the (Benzo[1,3]dioxol-5-ylamino)-acetic acid ethyl ester.
後処理
- customReaction
- customwas then quenched with water
- extractionextracted with ethyl acetate
- dry with materialdried over sodium sulphate
- concentrationconcentrated under reduced pressure
- customto afford crude product, which
- customon purification by column chromatography
出典と根拠
- ORDレコード
- ord-6c3822dff14744c8af4d2fbfc545ec6d
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08440830B2
反応ノート
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