Sodium Hydroxide → 4-(1,1-Dioxo-1,2-thiazolidin-2-yl)-3-methylbenzoic acid

HRID 2094271ノート

反応式

HRID 2094271 の反応式
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][C:8]=1[CH3:17].[OH-].[Na+]>C(O)C>[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=1[CH3:17]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 67048536Methyl 4-(1,1-dioxo-isothiazolidin-2-yl)-3-methyl-benzoate

生成物 1

HCID 246888114-(1,1-Dioxo-1,2-thiazolidin-2-yl)-3-methylbenzoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

170 mg (0.63 mmol) methyl 4-(1,1-dioxo-isothiazolidin-2-yl)-3-methyl-benzoate are stirred in 2 ml of ethanol at ambient temperature for 3 hours with 0.6 ml of 2-molar sodium hydroxide solution. Then the reaction solution is evaporated down i. vac., combined with water and 0.6 ml 2-molar hydrochloric acid and extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate, evaporated down i. vac. and the residue is further reacted without any more purification.

後処理

  1. customThen the reaction solution is evaporated down i
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined organic phases are dried over sodium sulphate
  4. customevaporated down i
  5. customand the residue is further reacted without any more purification

出典と根拠

ORDレコード
ord-01eff931c5b14c6f997e3776d86419b1
出典データセット
uspto-grants-2013_05
特許番号
US08445525B2

反応ノート

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