Hydrochloric Acid → 2-oxo-1-(o-tolyl)-1,2-Dihydropyridine-3-carboxylic acid
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16]C)=[O:15])[C:9]1=[O:18].[OH-].[Na+].Cl>CO>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([OH:16])=[O:15])[C:9]1=[O:18]参加物
5
実験手順
To a solution (9 mL) of methyl 1-(2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate (880 mg, 3.62 mmol) in methanol was added 1N aqueous sodium hydroxide solution (5 mL), and the mixture was stirred at room temperature for 4 hr. The reaction mixture was adjusted to pH<7 with 1N hydrochloric acid and concentrated under reduced pressure. The precipitate was collected by filtration and washed with water to give the title compound (704 mg, 85%) as yellow crystals.
後処理
- concentrationconcentrated under reduced pressure
- filtrationThe precipitate was collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-b852c9d83c844046b7e3b55f98249303
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08445509B2
反応ノート
読み込み中…