[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[C:10]([C:18]#N)[C:9]2=[O:20])=[CH:4][CH:3]=1.[OH2:21].[OH-:22].[Na+]>S(=O)(=O)(O)O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[C:10]([C:18]([OH:22])=[O:21])[C:9]2=[O:20])=[CH:4][CH:3]=1A solution of 1-(4-fluorophenyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (200 mg, 0.709 mmol) in conc. sulfuric acid (1.5 mL)/water (1.5 mL) was stirred at 120° C. for 17 hr. The reaction solution was allowed to cool to room temperature, 6N aqueous sodium hydroxide solution was added, and the aqueous layer was washed with ethyl acetate. 1N Hydrochloric acid was added to the aqueous layer, and the precipitate was filtered and washed with water to give the title compound (160 mg, 75%) as a white solid.
読み込み中…
