Trifluoroacetic acid → N-(Azetidin-3-ylcarbamoylmethyl)-2,5-bis-trifluoromethyl-benzamide TFA salt
反応式
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C(OC([N:15]1[CH2:18][CH:17]([NH:19][C:20](=[O:39])[CH2:21][NH:22][C:23](=[O:38])[C:24]2[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][C:25]=2[C:34]([F:37])([F:36])[F:35])[CH2:16]1)=O)(C)(C)C>>[OH:7][C:1]([C:3]([F:6])([F:5])[F:4])=[O:2].[NH:15]1[CH2:18][CH:17]([NH:19][C:20]([CH2:21][NH:22][C:23](=[O:38])[C:24]2[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][C:25]=2[C:34]([F:35])([F:37])[F:36])=[O:39])[CH2:16]1参加物
3
実験手順
The title compound was prepared as colorless oil from TFA de-protection of 3-[2-(2,5-bis-trifluoromethyl-benzoylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butylester using the procedure described in Step D of Example 1.
出典と根拠
- ORDレコード
- ord-624d23afc55f4136b4ac18ebcd6586f4
- 出典データセット
- uspto-grants-2013_05