Hydroxyamine hydrochloride → HCID 76688560、化合物
反応式
Cl.[NH2:2][OH:3].[F:4][C:5]1[C:12]([I:13])=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=O>C(O)C>[F:4][C:5]1[C:12]([I:13])=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[N:2][OH:3]参加物
4
実験手順
A 50% aqueous solution of hydroxylamine hydrochloride (9 mL, 64.8 mmol) was added to a stirred suspension of 2-fluoro-3-iodobenzaldehyde (preparation 22d, 2.10 g, 8.4 mmol) in ethanol (10 mL) and the mixture was warmed slightly until a solution was formed. After stirring for 3 days at room temperature, the mixture was concentrated in vacuo and water was added to the residue. The mixture was extracted with ethyl acetate and the organic layer was washed with brine, dried (MgSO4) and evaporated to give the title compound (2.15 g, 97%) as a solid.
後処理
- temperaturethe mixture was warmed slightly until a solution
- customwas formed
- concentrationthe mixture was concentrated in vacuo and water
- additionwas added to the residue
- extractionThe mixture was extracted with ethyl acetate
- washthe organic layer was washed with brine
- dry with materialdried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-43a87c5b3b494852bb33b22d56ad74b3
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08450341B2
反応ノート
読み込み中…