Hydrazine hydrate (1:1) → Pyridine, 2-hydrazinyl-3-iodo-

HRID 2096982ノート

反応式

HRID 2096982 の反応式
O.[NH2:2][NH2:3].F[C:5]1[C:10]([I:11])=[CH:9][CH:8]=[CH:7][N:6]=1>C(O)C>[NH:2]([C:5]1[C:10]([I:11])=[CH:9][CH:8]=[CH:7][N:6]=1)[NH2:3]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 70095012-Fluoro-3-iodopyridine

生成物 1

HCID 53402765Pyridine, 2-hydrazinyl-3-iodo-収率 46%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Hydrazine hydrate (12.50 mL, 256 mmol) was added dropwise to a solution of 2-fluoro-3-iodopyridine (preparation 26a, 5.72 g, 25.7 mmol) in ethanol (43 mL) and the resulting mixture was stirred at room temperature for 24 hours and then at 35° C. for a further 24 hours. The solvent was then evaporated in vacuo and water was added. The white solid that formed was filtered, washed with water and dried to yield the title compound (2.78 g, 46%) as a white solid which was used without further purification.

後処理

  1. waitat 35° C. for a further 24 hours
  2. customThe solvent was then evaporated in vacuo and water
  3. additionwas added
  4. customThe white solid that formed
  5. filtrationwas filtered
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-a0ca4898366e42b3adf9538e66b721b8
出典データセット
uspto-grants-2013_05
特許番号
US08450341B2

反応ノート

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