Acetic Acid → NH3 MeOH EtOH

HRID 2097224ノート

反応式

HRID 2097224 の反応式
[CH3:1][N:2]([CH3:14])[CH2:3][CH:4]([C:9]1[CH:13]=[CH:12][S:11][CH:10]=1)[C:5]([O:7]C)=[O:6].[Li+].[OH-].O.[CH3:18][C:19](O)=[O:20]>C1COCC1.O.CO>[NH3:2].[CH3:5][OH:6].[CH3:18][CH2:19][OH:20].[CH3:14][N:2]([CH3:1])[CH2:3][CH:4]([C:9]1[CH:13]=[CH:12][S:11][CH:10]=1)[C:5]([OH:7])=[O:6]

参加物

7

反応物 4

HCID 176Acetic AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 59161743Methyl 3-(dimethylamino)-2-(thiophen-3-yl)propanoate

生成物 2

HCID 591617463-(Dimethylamino)-2-(thiophen-3-yl)propanoic acidHCID 86638423NH3 MeOH EtOH収率 10%

試薬・触媒・溶媒 1

HCID 21892291Methanol tetrahydrofuran water溶媒

実験手順

To methyl 3-(dimethylamino)-2-(thiophen-3-yl)propanoate (E42) in THF/H2O/MeOH was added LiOH*H2O, and the solution was stirred for 12 hours. AcOH was added and the solvents were evaporated. Column chromatography (SiO2, 10-15% 2M NH3-MeOH/EtOH) gave pure 3-(dimethylamino)-2-(thiophen-3-yl)propanoic acid (E43).

後処理

  1. customthe solvents were evaporated

出典と根拠

ORDレコード
ord-1e0f8c803cb846c3ba5254882ff5c6d5
出典データセット
uspto-grants-2013_05
特許番号
US08450344B2

反応ノート

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