Water → 1-(2,4-Bis-benzyloxy-5-bromo-phenyl)-ethanone

HRID 2097270ノート

反応式

HRID 2097270 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[C:23](=[O:25])[CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:26]N1C(=O)CCC1=O.O>CN(C=O)C>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:12]([Br:26])=[CH:11][C:10]=1[C:23](=[O:25])[CH3:24])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 3194691-(2,4-Bis(benzyloxy)phenyl)ethanone

生成物 1

HCID 247744411-(2,4-Bis-benzyloxy-5-bromo-phenyl)-ethanone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

51.2 g of 1-(2,4-Bis-benzyloxy-phenyl)-ethanone (0.154 mol, 1 eq) were dissolved in 250 ml DMF. 27.42 g N-bromosuccinimide (0.154 mol, 1 eq) in 100 ml DMF were added dropwise. The mixture was stirred at room temperature over night. The reaction mixture was poured onto 700 ml of water and the precipitate filtered off. The filter cake was rinsed with water and the colourless solid was recrystallised from 370 ml acetonitrile.

後処理

  1. filtrationthe precipitate filtered off
  2. washThe filter cake was rinsed with water
  3. customthe colourless solid was recrystallised from 370 ml acetonitrile

出典と根拠

ORDレコード
ord-33b1552949b14b74b3519fc997b151de
出典データセット
uspto-grants-2013_05
特許番号
US08450310B2

反応ノート

読み込み中…