Phenylboronic Acid → 5-Benzyl-2-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-3-phenyl-1-(2-trimethylsilylethoxymethyl)-1,5-dihydropyrrolo[2,3-d]pyridazin-4-one

反応式

[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[C:15](I)=[C:16]([C:26]3[CH:31]=[CH:30][C:29]([O:32][CH:33]([F:35])[F:34])=[C:28]([O:36][CH2:37][CH:38]4[CH2:40][CH2:39]4)[CH:27]=3)[N:17]([CH2:18][O:19][CH2:20][CH2:21][Si:22]([CH3:25])([CH3:24])[CH3:23])[C:11]=2[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.BrC1N(COCC[Si](C)(C)C)C2C=NNC(=O)C=2C=1.[C:61]1(B(O)O)[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=1.C1(P(C2CCCCC2)C2C=CC=CC=2C2C(OC)=CC=CC=2OC)CCCCC1>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.O1CCCC1>[CH2:1]([N:8]1[C:13](=[O:14])[C:12]2[C:15]([C:61]3[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=3)=[C:16]([C:26]3[CH:31]=[CH:30][C:29]([O:32][CH:33]([F:35])[F:34])=[C:28]([O:36][CH2:37][CH:38]4[CH2:40][CH2:39]4)[CH:27]=3)[N:17]([CH2:18][O:19][CH2:20][CH2:21][Si:22]([CH3:25])([CH3:24])[CH3:23])[C:11]=2[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1