Hydrazine hydrate (1:1) → 5-Chloro-4-hydrazinylthieno[2,3-d]pyrimidine

HRID 2098039ノート

反応式

HRID 2098039 の反応式
[Cl:1][C:2]1[C:10]2[C:9](Cl)=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1.O.[NH2:13][NH2:14]>C(O)C>[Cl:1][C:2]1[C:10]2[C:9]([NH:13][NH2:14])=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 157457684,5-Dichlorothieno[2,3-d]pyrimidine

生成物 1

HCID 157460705-Chloro-4-hydrazinylthieno[2,3-d]pyrimidine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5-Chloro-4-chlorothieno[2,3-d]pyrimidine (1.38 g, 6.73 mmol) and hydrazine monohydrate (5.0 ml, 103 mmol) in absolute ethanol (20 ml) were heated at 75° C. After stirring for 24 h, the solution was concentrated to yield 5-chloro-4-hydrazinylthieno[2,3-d]pyrimidine. Method [6] Retention time 0.35 min by HPLC (M+=201 and 203).

後処理

  1. concentrationthe solution was concentrated

出典と根拠

ORDレコード
ord-4ef83b4d20f94118b48170ed044cccc0
出典データセット
uspto-grants-2013_05
特許番号
US08450363B2

反応ノート

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