N-bromobutanimide → 5-Fluoro-2-iodo-4-trifluoromethyl-phenylamine

HRID 2098106ノート

反応式

HRID 2098106 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10])[NH2:5].C1C(=O)N([Br:20])C(=O)C1>C(Cl)Cl>[Br:20][C:6]1[CH:7]=[C:8]([C:9]([F:10])([F:11])[F:12])[C:2]([F:1])=[CH:3][C:4]=1[NH2:5]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 27359144-Amino-2-fluorobenzotrifluoride

生成物 1

HCID 687591875-Fluoro-2-iodo-4-trifluoromethyl-phenylamine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a stirring mixture of 3-fluoro-4-(trifluoromethyl)aniline (1.5 g) in DCM (12 mL) at room temperature was added dropwise a solution of NBS (1.5 g) in DCM (24 mL) over 15 min. The reaction mixture was stirred at rt for 1.5 h. The product mixture was concentrated under reduced pressure to one half of its original volumn. The white solid was filtered off and the crude product mixture was further purified via column chromatography. Retention time (min)=2.490, method [1], MS (ESI) 257.9 (M+H).

後処理

  1. concentrationThe product mixture was concentrated under reduced pressure to one half of its original volumn
  2. filtrationThe white solid was filtered off
  3. customthe crude product mixture was further purified via column chromatography

出典と根拠

ORDレコード
ord-3abb1aa54f554404833c0b7198a05abd
出典データセット
uspto-grants-2013_05
特許番号
US08450363B2

反応ノート

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