2-Methoxyethylamine → 2-(1H-indazol-4-yl)-N-(2-methoxyethyl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

HRID 2098691ノート

反応式

[NH:1]1[C:9]2[C:4](=[C:5]([C:10]3[N:11]=[C:12]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)[C:13]4[S:18][C:17]([C:19]([OH:21])=O)=[CH:16][C:14]=4[N:15]=3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[CH3:28][O:29][CH2:30][CH2:31][NH2:32]>>[NH:1]1[C:9]2[C:4](=[C:5]([C:10]3[N:11]=[C:12]([N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)[C:13]4[S:18][C:17]([C:19]([NH:32][CH2:31][CH2:30][O:29][CH3:28])=[O:21])=[CH:16][C:14]=4[N:15]=3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1

参加物

反応物 2

HCID 80182-Methoxyethylamine

HCID 595931412-(1H-Indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid

生成物 1

HCID 595930382-(1H-indazol-4-yl)-N-(2-methoxyethyl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxamide

実験手順

45 mg of 2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carboxylic acid 13 was coupled to 2-methoxyethanamine via General Procedure B. The product was purified via reverse phase HPLC to give 18.8 mg of 188. MS (Q1) 439.1 (M)+.

後処理

customThe product was purified via reverse phase HPLC

出典と根拠

ORDレコード: ord-0642bfc93d6c4325806bb43de5193216
出典データセット: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08450315B2

反応ノート

読み込み中…