HCID 59590766、化合物 → HCID 59590767、化合物
反応式
C([O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH2:13][CH2:14]/[C:15]/2=[CH:18]\[C:19]([O:21][CH3:22])=[O:20])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].CO>[OH:8][C:9]1[CH:17]=[C:16]2[C:12]([CH2:13][CH2:14][CH:15]2[CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:11][CH:10]=1参加物
4
実験手順
Under hydrogen, a mixture of (E)-methyl 2-(6-(benzyloxy)-2,3-dihydroinden-1-ylidene)acetate (1.3) (1.64 g, 5.57 mmol), palladium on carbon (10%) (0.462 g, 3.90 mmol) in MeOH (30 mL) were stirred for 24 hours. The mixture was then filtered through silica gel to remove the Pd—C, eluting with EtOAc. After removing solvent by rotary evaporation, the residue was purified using column chromatography (1:1 EtOAc/hexane). Product 1.4 was obtained in 68% yield as a colorless oil.
後処理
- filtrationThe mixture was then filtered through silica gel
- customto remove the Pd—C
- washeluting with EtOAc
- customAfter removing solvent
- customby rotary evaporation
- customthe residue was purified
出典と根拠
- ORDレコード
- ord-ad60695382604aa0af26673dfed734bd
- 出典データセット
- uspto-grants-2013_05
- 特許番号
- US08450522B2
反応ノート
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