Dibutyltin dichloride → 5-Bromo-3-(2,2-dimethyl-[1,3]dioxan-5-ylamino)-thiophene-2-carboxylic acid methyl ester

HRID 2099658

反応式

HRID 2099658 の反応式
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([Br:11])=[CH:8][C:9]=1[NH2:10])=[O:4].[CH3:12][C:13]1([CH3:20])[O:18][CH2:17][C:16](=O)[CH2:15][O:14]1.C([Sn](Cl)(Cl)CCCC)CCC.C1([SiH3])C=CC=CC=1>C1COCC1.C(OCC)(=O)C>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([Br:11])=[CH:8][C:9]=1[NH:10][CH:16]1[CH2:17][O:18][C:13]([CH3:20])([CH3:12])[O:14][CH2:15]1)=[O:4]

参加物

7

反応物 4

HCID 12688Dibutyltin dichlorideHCID 12752PhenylsilaneHCID 27331412,2-Dimethyl-1,3-dioxan-5-oneHCID 20158931Methyl 3-amino-5-bromothiophene-2-carboxylate

生成物 1

HCID 577954295-Bromo-3-(2,2-dimethyl-[1,3]dioxan-5-ylamino)-thiophene-2-carboxylic acid methyl ester収率 29.6%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A suspension of 3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester (0.5 g, 2.12 mmol) in dry THF (0.6 mL) was treated with 2,2-dimethyl-[1,3]dioxan-5-one (253 μl, 2.12 mmol), followed by dibutyltin dichloride (32 mg, 0.11 mmol). After 5 min phenyl silane (280 μl, 2.27 mmol) was added and the reaction was stirred at room temperature for 3 days. It was dissolved in ethyl acetate (100 mL), washed with NaHCO3 solution and brine. The organic layer was separated, dried over MgSO4, evaporated and left on vacuum pump overnight. The residue was triturated with hexane-ether (4:1) mixture (2×100 mL). The soluble portion was evaporated and purified by chromatography over silica gel (hexane:ethyl acetate—95:5) yielding pure 5-bromo-3-(2,2-dimethyl-[1,3]dioxan-5-ylamino)-thiophene-2-carboxylic acid methyl ester (220 mg, 29%).

後処理

  1. washwashed with NaHCO3 solution and brine
  2. customThe organic layer was separated
  3. dry with materialdried over MgSO4
  4. customevaporated
  5. waitleft on vacuum pump overnight
  6. customThe residue was triturated with hexane-ether (4:1) mixture (2×100 mL)
  7. customThe soluble portion was evaporated
  8. custompurified by chromatography over silica gel (hexane:ethyl acetate—95:5)

出典と根拠

ORDレコード
ord-fe12b696efce4849ad2718668aea6804
出典データセット
uspto-grants-2009_08
特許番号
US07569600B2

関連ノート

読み込み中…