benzyl 2-(7-methyl-1H-indazol-5-yl)-1-(1-neopentyl-1H-tetrazol-5-yl)ethylcarbamate → HCID 57794577、化合物
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:11][CH:12]([NH:23]C(=O)OCC2C=CC=CC=2)[C:13]2[N:17]([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])[N:16]=[N:15][N:14]=2)[CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[CH:7]2>CO.[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([CH2:11][CH:12]([C:13]2[N:17]([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])[N:16]=[N:15][N:14]=2)[NH2:23])[CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[CH:7]2参加物
4
実験手順
A solution of benzyl 2-(7-methyl-1H-indazol-5-yl)-1-(1-neopentyl-1H-tetrazol-5-yl)ethylcarbamate (70.0 mg, 0.156 mmol) in methanol (2.0 mL) was flushed with nitrogen, and treated with palladium (10% on charcoal, 7.0 mg). The flask was flushed with hydrogen and allowed to stir under a balloon of hydrogen overnight. The reaction was flushed with nitrogen, filtered through celite, and concentrated. Column chromatography gave 48.0 mg (quant.). Mass spec.: 314.17 (MH)+.