Thionyl Chloride → 2-Chloro-4-(chloromethyl)-6-methylpyridine

HRID 2099825ノート

反応式

HRID 2099825 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[CH:5]=[C:4]([CH3:10])[N:3]=1.S(Cl)([Cl:13])=O>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][Cl:13])[CH:5]=[C:4]([CH3:10])[N:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 22504306(2-Chloro-6-methylpyridin-4-yl)methanol

生成物 1

HCID 216981672-Chloro-4-(chloromethyl)-6-methylpyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(2-Chloro-6-methylpyridin-4-yl)methanol (0.212 g, 1.35 mmol) and thionyl chloride (0.12 mL, 1.62 mmol) were combined in methylene chloride (4 mL) and stirred at room temperature for 4 h. The solvents were removed and the product dried under vacuum for several hours to afford 0.24 g (quant.) as a clear oil which was used without purification. Mass spec.: 176.0 (MH)+.

後処理

  1. customThe solvents were removed
  2. customthe product dried under vacuum for several hours
  3. customto afford 0.24 g (quant.) as a clear oil which
  4. customwas used without purification

出典と根拠

ORDレコード
ord-2f6899c5c0574523b8288fa8836090b8
出典データセット
uspto-grants-2009_08
特許番号
US07569578B2

反応ノート

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