Bromine → 2-Bromo-6-nitro-1H-benzimidazole
反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:11]=[C:10](S)[NH:9][C:8]=2[CH:13]=1)([O-:3])=[O:2].[Br:14]Br>CO.Br>[Br:14][C:10]1[NH:9][C:8]2[CH:13]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][C:7]=2[N:11]=1参加物
5
反応条件
- 温度
- 7.5 °C
実験手順
A suspension of 5.0 g (25.61 mmol) of 6-nitro-1H-benzimidazole-2-thiol in 30 ml of methanol and 10 ml of hydrogen bromide (48% in water) was cooled to 5-10° C. and admixed with 5.7 ml (111 mmol) of bromine. Subsequently, the mixture was stirred at 5-10° C. for 1.5 hours and poured onto ice-water. The red precipitate was filtered off with suction, washed with water and dried at 40° C. under reduced pressure. 4.82 g (78%) of the desired product were obtained.
後処理
- additionpoured onto ice-water
- filtrationThe red precipitate was filtered off with suction
- washwashed with water
- customdried at 40° C. under reduced pressure
出典と根拠
- ORDレコード
- ord-27d278947a774572a90fff758c4f3809
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07569700B2
反応ノート
読み込み中…