3,3,5,5-Tetramethylcyclohexanone → 4-[{4-[(2-Hydroxyethyl)oxy]phenyl}(3,3,5,5-tetramethylcyclohexylidene)methyl]phenol

HRID 2100102

反応式

HRID 2100102 の反応式
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)=O)=[CH:7][CH:6]=1.[CH3:20][C:21]1([CH3:30])[CH2:26][C:25]([CH3:28])([CH3:27])[CH2:24][C:23](=O)[CH2:22]1>C1COCC1.[Zn].Cl[Ti](Cl)(Cl)Cl>[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11](=[C:23]2[CH2:24][C:25]([CH3:28])([CH3:27])[CH2:26][C:21]([CH3:30])([CH3:20])[CH2:22]2)[C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1

参加物

6

反応物 2

HCID 843993,3,5,5-TetramethylcyclohexanoneHCID 68654819(4-(2-Hydroxyethoxy)phenyl)(4-hydroxyphenyl)methanone

生成物 1

HCID 112690074-[{4-[(2-Hydroxyethyl)oxy]phenyl}(3,3,5,5-tetramethylcyclohexylidene)methyl]phenol収率 42%

試薬・触媒・溶媒 3

HCID 23994Zinc触媒HCID 24193Titanium Tetrachloride触媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a stirred suspension of Zn (0.50 g, 7.59 mmol) in THF (10 mL) was added TiCl4 (0.42 mL, 3.79 mmol) dropwise. The mixture was refluxed under nitrogen for 2.5 h. Cooled to room temperature, a solution of 96 (0.245 g, 0.95 mmol) and 3,3,5,5-tetramethylcyclohexanone (0.45 g, 2.85 mmol) in THF (15 mL) was added at once. The reaction mixture was refluxed for another 2.5 h. Cooled to room temperature, the reaction was quenched with 10% K2CO3 (20 mL). The quenched reaction mixture was filtered through a pad of Celite and the pad washed with EtOAc (100 mL). The filtrate was transferred to a separatory funnel, the layers were separated and the aqueous phase was extracted with EtOAc (50 mL). The organic extracts were combined, washed with brine and dried (Na2SO4). Concentration yielded a pale brown oil which was further purified by chromatography on a silica gel column eluted with a gradient from hexanes to 45% EtOAc:hexanes to give a light yellow solid, Crystallization from 7:1 hexanes:EtOAc yielded 97 as colorless needles (0.15 g, 42%). mp 154-155° C. 1H NMR (400 MHz, CD3OD): δ 0.91 (s, 6H), 0.92 (s, 6H), 1.28 (s, 2H), 1.96 (s, 2H), 1.98 (s, 2H), 3.80-3.90 (m, 2H), 4.00-4.10 (m, 2H), 6.67 (d, J=8.5 Hz, 2H), 6.84 (d, J=8.6 Hz, 2H), 6.94 (d, J=8.6 Hz, 2H), 7.03 (d, J=8.6 Hz, 2H). LRMS (ESI): m/z 381 (M+H)+, 379 (M−H)−. The sample was silated prior to EI analysis. HRMS (EI) Calcd for C31H48O3Si2: 524.3142 (M+). Found: 524.3128.

後処理

  1. temperatureThe mixture was refluxed under nitrogen for 2.5 h
  2. temperatureThe reaction mixture was refluxed for another 2.5 h
  3. temperatureCooled to room temperature
  4. customthe reaction was quenched with 10% K2CO3 (20 mL)
  5. customThe quenched reaction mixture
  6. filtrationwas filtered through a pad of Celite
  7. washthe pad washed with EtOAc (100 mL)
  8. customThe filtrate was transferred to a separatory funnel
  9. customthe layers were separated
  10. extractionthe aqueous phase was extracted with EtOAc (50 mL)
  11. washwashed with brine
  12. dry with materialdried (Na2SO4)
  13. concentrationConcentration
  14. customyielded a pale brown oil which
  15. customwas further purified by chromatography on a silica gel column
  16. washeluted with a gradient from hexanes to 45% EtOAc
  17. customhexanes to give
  18. customa light yellow solid, Crystallization from 7:1 hexanes

出典と根拠

ORDレコード
ord-7fb51ac998ff46b78bc84b8cf26dccf5
出典データセット
uspto-grants-2009_08
特許番号
US07569601B2

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