Hydrochloric Acid → 3-(4-Fluoro-3-methoxyphenyl)prop-2-enoic acid
反応式
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[O:10][CH3:11].C(O)(=O)[CH2:13][C:14]([OH:16])=[O:15].Cl>N1C=CC=CC=1.N1CCCCC1>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:13][C:14]([OH:16])=[O:15])=[CH:4][C:3]=1[O:10][CH3:11]参加物
6
反応条件
- 温度
- 120 °C
実験手順
A mixture of 4-Fluoro-3-methoxy-benzaldehyde (6.16 g, 40 mmol), and malonic acid (6.24 g, 60 mmol) in pyridine (30 ml) and piperidine (1 ml) was heated at 120° C. for 2 hrs. The mixture was cooled to room temperature and neutralized with concentrated HCl to PH<3, the white solid was collected and dried to give 7.6 g of product (97% yield). LC-MS: m/e 195 (M−1)
後処理
- customthe white solid was collected
- customdried
出典と根拠
- ORDレコード
- ord-7c2cf292a17f448dae2c111e5cf6b23e
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07572809B2
反応ノート
読み込み中…