3-(4-Fluoro-3-methoxyphenyl)prop-2-enoic acid → 3-(4-Fluoro-3-methoxyphenyl)propanoic acid
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:4][C:3]=1[O:13][CH3:14].[H][H]>C(OCC)(=O)C.CO.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][C:3]=1[O:13][CH3:14]参加物
6
実験手順
3-(4-Fluoro-3-methoxy-phenyl)-acrylic acid (6.2 g, 31.6 mmol) and Pd—C (10%, 620 mg) in ethyl acetate and methanol (1:1, 400 ml) was placed in a Parr apparatus. After the appropriate amount of hydrogen was taken up, the catalyst was filtered and the filtrate was concentrated in vacuo to give 6.2 g white solid (99% yield). LC-MS: m/e 197 (M−1)
後処理
- filtrationthe catalyst was filtered
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-6f7d20897a1a4db185d7b0e41e78a833
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07572809B2
反応ノート
読み込み中…