3-(3,5-Dimethoxyphenyl)-2-propenoic acid → 3-(3,5-dimethoxyphenyl)propanoic Acid
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][C:13]([OH:15])=[O:14])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[H][H]>CCOC(C)=O.CO.[Pd]>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1参加物
6
実験手順
To a solution of 3-(3,5-Dimethoxy-phenyl)-acrylic acid (12 g, 57.7 mmol) in EtOAc (100 ml) and MeOH (100 ml) was added carefully 10% Pd/C (1.3 g), the reaction mixture was shaken in Parr apparatus for 5 hs under 30-40 psi of hydrogen, then the solution was passed through a celite pad, the filtrate was concentrated and dried at 50° C. under reduced pressure to give product (11.7 g, 96.55%). LC-MS: m/e 209 (M−1)
後処理
- concentrationthe filtrate was concentrated
- customdried at 50° C. under reduced pressure
出典と根拠
- ORDレコード
- ord-bb3c3a4adc5149298826fbbfc87413f7
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07572809B2
反応ノート
読み込み中…