Lithium hydroxide, monohydrate → 2,3-Dihydro-6-methoxy-3-oxo-1H-indene-5-carboxylic acid

HRID 2100750ノート

反応式

HRID 2100750 の反応式
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[CH2:10][CH2:9][C:8]2=[O:16])=[O:4].O[Li].O>C1COCC1.O>[CH3:15][O:14][C:13]1[CH:12]=[C:11]2[C:7]([C:8](=[O:16])[CH2:9][CH2:10]2)=[CH:6][C:5]=1[C:3]([OH:4])=[O:2]

参加物

5

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 57799525HCID 57799525、化合物

生成物 1

HCID 537374072,3-Dihydro-6-methoxy-3-oxo-1H-indene-5-carboxylic acid収率 90.2%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

6-Methoxy-3-oxo-indan-5-carboxylic acid methyl ester (4 g, 18.18 mmol) was added to a solution of LiOH.H2O (2.2 g, 54.5 mmol) in THF (40 ml) and H2O (40 ml), then the mixture was heated to reflux and stirred for one hour. After removal of THF, the residue was acidified to PH=3, and the precipitate was collected and dried to give a white solid (3.38 g, 89.8%). LC-MS: m/e 207 (MH+)

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux
  3. customAfter removal of THF
  4. customthe precipitate was collected
  5. customdried

出典と根拠

ORDレコード
ord-5dd27c492fec41a382126e7032e88c80
出典データセット
uspto-grants-2009_08
特許番号
US07572809B2

反応ノート

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