tert-butyl 4-nitro-1H-indazole-1-carboxylate → tert-Butyl 4-amino-1H-indazole-1-carboxylate
反応式
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[N:7][N:8]2[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[N:7][N:8]2[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14]参加物
4
実験手順
1,1-Dimethylethyl 4-nitro-1H-indazole-1-carboxylate (1.2 g) was dissolved in ethanol (150 ml) and stirred with 10% palladium on carbon (0.24 g) under an atmosphere of hydrogen (1 atmosphere pressure) for 18 h. The solution was filtered through a pad of celite and the filtrate concentrated in vacuo to give the title compound as a yellow-orange solid (1.03 g).
後処理
- filtrationThe solution was filtered through a pad of celite
- concentrationthe filtrate concentrated in vacuo
出典と根拠
- ORDレコード
- ord-ac0c81a5fe944f0f82b75a9faca18b61
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07572915B2
反応ノート
読み込み中…