1-Aminopiperidine → N-(Piperidin-1-yl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide

HRID 2101719

反応式

HRID 2101719 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([C:22](OCC)=[O:23])[N:11]([CH3:21])[C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[Cl:20])=[CH:4][CH:3]=1.[NH2:27][N:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[N:28]1([NH:27][C:22]([C:10]2[N:11]([CH3:21])[C:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[N:9]=2)=[O:23])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1

参加物

3

反応物 2

HCID 166581-AminopiperidineHCID 22066075Ethyl 4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxylate

生成物 1

HCID 10183243N-(Piperidin-1-yl)-4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxamide

反応条件

温度
90 °C

実験手順

A mixture of ethyl 4-(4-chlorophenyl)-5-(2,4-dichlorophenyl)-1-methylimidazole-2-carboxylate (50 mg, 0.125 mmol) from Step D in neat 1-aminopiperidine (1 mL) was heated at 90° C. for 72 hr. Most of the amine was evaporated under a stream of nitrogen and the residue was purified by Prep TLC (2×1 mm, silica) (40% ethyl acetate in hexanes to afford the title compound.

後処理

  1. customMost of the amine was evaporated under a stream of nitrogen
  2. customthe residue was purified by Prep TLC (2×1 mm, silica) (40% ethyl acetate in hexanes

出典と根拠

ORDレコード
ord-32a9b6ea237a4719b9ecba72c5ce1b06
出典データセット
uspto-grants-2009_08
特許番号
US07572785B2

関連ノート

読み込み中…