N-bromobutanimide → HCID 178470082、化合物

HRID 2102258ノート

反応式

HRID 2102258 の反応式
[OH:1][C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:4]([CH:12]([CH3:14])[CH3:13])[N:3]=1.[Br:15]N1C(=O)CCC1=O>ClCCl>[Br:15][C:5]1[N:4]([CH:12]([CH3:13])[CH3:14])[N:3]=[C:2]([OH:1])[C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 178469772Ethyl 3-hydroxy-1-isopropylpyrazole-4-carboxylate

生成物 1

HCID 178470082HCID 178470082、化合物収率 40.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Ethyl 3-hydroxy-1-isopropylpyrazole-4-carboxylate (10.5 g) was dissolved in dichloromethane (100 mL) and to the stirred solution was added N-bromosuccinimide (14.1 g) under ice cooling. The reaction mixture was stirred at room temperature for 6 hours. The solvent was removed under reduced pressure and the obtained residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=1/5) to give 5.9 g of the title compound.

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe obtained residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=1/5)

出典と根拠

ORDレコード
ord-1f83431b0f7d4bb0a2940084453d2648
出典データセット
uspto-grants-2009_08
特許番号
US07576064B2

反応ノート

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