N-bromobutanimide → HCID 178470082、化合物
反応式
[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:14])=[N:8][N:9]([CH:11]([CH3:13])[CH3:12])[CH:10]=1)=[O:5])[CH3:2].[Br:15]N1C(=O)CCC1=O>ClCCl>[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:14])=[N:8][N:9]([CH:11]([CH3:13])[CH3:12])[C:10]=1[Br:15])=[O:5])[CH3:2]参加物
4
実験手順
3-Hydroxy-1-isopropylpyrazole-4-carboxylic acid ethyl ester (10.5 g) was dissolved in dichloromethane (100 mL), and N-bromosuccinimide (14.1 g) was added to the solution under ice cooling. The mixture was stirred at room temperature for 6 hours. The solvent was removed under reduced pressure, and the obtained residue was purified by column chromatography on silica gel (eluent:ethyl acetate/hexane=1/5) to give the title compound (5.9 g)
後処理
- customThe solvent was removed under reduced pressure
- customthe obtained residue was purified by column chromatography on silica gel (eluent:ethyl acetate/hexane=1/5)
出典と根拠
- ORDレコード
- ord-239871e0407d422fa1cb5fe1152071ee
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07576063B2
反応ノート
読み込み中…