Cesium fluoride → HCID 59519383、化合物
反応式
[CH3:1][O:2][C:3]([C:5]1[C:10]([Cl:11])=[C:9](Cl)[C:8]([Cl:13])=[C:7]([Cl:14])[N:6]=1)=[O:4].[F-:15].[Cs+]>CC#N.CCOC(C)=O.O>[CH3:1][O:2][C:3]([C:5]1[C:10]([Cl:11])=[C:9]([F:15])[C:8]([Cl:13])=[C:7]([Cl:14])[N:6]=1)=[O:4]参加物
6
実験手順
To a solution of 3,4,5,6-tetrachloropyridine-2-carboxylic acid methyl ester (1.00 equivalent) in MeCN is added CsF (1.00 equivalent) at room temperature. The resulting mixture is refluxed with stirring for 16 hours. The reaction mixture is cooled to room temperature and diluted with EtOAc and water. The organic layer is washed with brine, dried over MgSO4, filtered, and concentrated in vacuo to afford the desired product that is purified by flash column chromatography as necessary.
後処理
- temperatureThe resulting mixture is refluxed
- washThe organic layer is washed with brine
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-5d823a8fc9104659a5a1ed8909763bdb
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07576072B2
反応ノート
読み込み中…