2-Aminophenol → 4-Isocyanatophenol
反応式
[C:1](Cl)(Cl)=[O:2].[NH2:5][C:6]1[CH:11]=[CH:10]C=[CH:8][C:7]=1O.[C:13](OCC)(=[O:15])C>C1(C)C=CC=CC=1>[N:5]([C:6]1[CH:11]=[CH:10][C:1]([OH:2])=[CH:8][CH:7]=1)=[C:13]=[O:15]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a stirred solution of phosgene (20% in Toluene, 24 mL, 45.9 mmol) (Aldrich) in ethyl acetate (25 mL) at 0° C. was added aminophenol (0.5 g, 4.59 mmol) (Aldrich). The reaction mixture was stirred at 0° C. for 30 minutes and then heated at 80° C. for 3 hours. The mixture was cooling down to room temperature to give crude 4-isocyanato-phenol as 0.18 M solution in toluene and used for the next step without further purification.
後処理
- temperatureheated at 80° C. for 3 hours
- temperatureThe mixture was cooling down to room temperature
出典と根拠
- ORDレコード
- ord-c097451571db4f0f9f0c7e30225433c4
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07576082B2
反応ノート
読み込み中…