Methyl iodide → 4-Bromo-1-methanesulfonyl-2-(trifluoromethoxy)benzene
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5](S)=[C:4]([O:9][C:10]([F:13])([F:12])[F:11])[CH:3]=1.IC.[C:16](=O)([O-])[O-].[K+].[K+].BrC1C=CC(SC)=C(OC(F)(F)F)C=1.O[O:37][S:38]([O-:40])=O.[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:38]([CH3:16])(=[O:40])=[O:37])=[C:4]([O:9][C:10]([F:13])([F:12])[F:11])[CH:3]=1参加物
7
実験手順
Following the method of example 9a, reaction of 4-bromo-2-trifluoromethoxy-benzenethiol (1.0 g, 3.48 mmol) with iodomethane (0.238 mL, 3.82 mmol) and potassium carbonate (0.528 g, 3.82 mmol) in 13 mL acetone, followed by oxidation as described in example 39c, using 4-bromo-1-methylsulfanyl-2-trifluoromethoxy-benzene (0.78 g, 2.72 mmol) and oxone® (2.17 g, 3.54 mmol), stirring over night at r.t., addition of oxone® (0.84 g, 1.37 mmol), stirring over night at r.t., addition of oxone® (0.84 g, 1.37 mmol) and stirring over three days at r.t. affords the title compound without further chromatography as a white solid (0.81 g). MS (m/e): 320 (M+H).
後処理
- stirringstirring over night at r.t.
- stirringstirring over three days at r.t.
出典と根拠
- ORDレコード
- ord-5b68ea12096e497bbccaaf09405d7928
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07576108B2
反応ノート
読み込み中…