[C:1]1(=[O:11])[O:6][C:4](=[O:5])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[CH3:12][CH:13]([C:15]1[CH:16]=[CH:17][CH:18]=[C:19]([CH:22]([CH3:24])[CH3:23])[C:20]=1[OH:21])[CH3:14].C(N(CC)CC)C>CN(C1C=CN=CC=1)C.C(OCC)C>[CH:22]([C:19]1[CH:18]=[CH:17][CH:16]=[C:15]([CH:13]([CH3:14])[CH3:12])[C:20]=1[O:21][C:4]([C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[C:1]([OH:6])=[O:11])=[O:5])([CH3:24])[CH3:23]To a mixture of phthalic anhydride (0.84 g, 5.6 mmol) and propofol (1 g, 5.6 mmol) was added triethylamine (0.65 g, 6.4 mmol) and a catalytic amount of DMAP. The reaction mixture was brought to 90° C., stirred for 14 h, cooled to room temperature and diluted with ethyl ether (100 mL). The organic layer was washed with 10% aqueous citric acid solution (2×50 mL). The phases were separated and the organic phase was dried over MgSO4 and concentrated in vacuo. The crude product was sufficiently pure to be carried to the subsequent step.
読み込み中…
