Benzyl 2-[2,6-Bis(isopropyl)phenoxycarbonyloxy]-benzoate → 2-[2,6-Bis(isopropyl)phenoxycarbonyloxy]-benzoic Acid
反応式
[CH:1]([C:4]1[CH:29]=[CH:28][CH:27]=[C:26]([CH:30]([CH3:32])[CH3:31])[C:5]=1[O:6][C:7]([O:9][C:10]1[CH:25]=[CH:24][CH:23]=[CH:22][C:11]=1[C:12]([O:14]CC1C=CC=CC=1)=[O:13])=[O:8])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[CH:1]([C:4]1[CH:29]=[CH:28][CH:27]=[C:26]([CH:30]([CH3:32])[CH3:31])[C:5]=1[O:6][C:7]([O:9][C:10]1[CH:25]=[CH:24][CH:23]=[CH:22][C:11]=1[C:12]([OH:14])=[O:13])=[O:8])([CH3:3])[CH3:2]参加物
4
実験手順
To a suspension of 10% Pd—C (100 mg) in ethyl acetate (15 mL) under nitrogen was added a solution of compound (105) (0.7 g, 1.6 mmol) in ethyl acetate (5 mL). The resulting suspension was degassed three times and then hydrogen gas was introduced. The reaction mixture was stirred under 1 atm hydrogen atmosphere for 14 h, then filtered through a small plug of celite. The filtrate was concentrated in vacuo. The crude product (106) was carried to next step without further purification.