Trifluoroacetic acid → 2-{6-[1-Ethyl-3-(4-trifluoromethoxyphenyl)ureido]-5,6,7,8-tetrahydronaphthalen-2-ylsulfanyl}-2-methylpropionic acid

HRID 2104265ノート

反応式

HRID 2104265 の反応式
C([O:5][C:6](=[O:40])[C:7]([S:10][C:11]1[C:20](OC)=[CH:19][C:18]2[CH2:17][CH:16]([N:23]([CH2:38][CH3:39])[C:24]([NH:26][C:27]3[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:36])[F:35])=[CH:29][CH:28]=3)=[O:25])[CH2:15][CH2:14][C:13]=2[CH:12]=1)([CH3:9])[CH3:8])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:38]([N:23]([CH:16]1[CH2:15][CH2:14][C:13]2[CH:12]=[C:11]([S:10][C:7]([CH3:8])([CH3:9])[C:6]([OH:40])=[O:5])[CH:20]=[CH:19][C:18]=2[CH2:17]1)[C:24]([NH:26][C:27]1[CH:28]=[CH:29][C:30]([O:33][C:34]([F:37])([F:35])[F:36])=[CH:31][CH:32]=1)=[O:25])[CH3:39]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86601316HCID 86601316、化合物

生成物 1

HCID 102552732-{6-[1-Ethyl-3-(4-trifluoromethoxyphenyl)ureido]-5,6,7,8-tetrahydronaphthalen-2-ylsulfanyl}-2-methylpropionic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 2-{6-[1-ethyl-3-(4-trifluoromethoxyphenyl)ureido]-3-methoxy-5,6,7,8-tetrahydronaphthalen-2-ylsulfanyl}-2-methylpropionic acid tert butyl ester (0.02 g; 0.03 mmol) dissolved in CH2Cl2 (1.5 mL) was added TFA (1.5 mL) and the reaction mixture was stirred at room temperature for 1.5 h. The solvent was removed under reduced pressure and the residue was purified by reverse-phase semi-prep HPLC eluting with a MeCN—H2O gradient to yield 2-{6-[1ethyl-3-(4-trifluoromethoxyphenyl)ureido]-5,6,7,8-tetrahydronaphthalen-2-ylsulfanyl}-2-methylpropionic acid as a white solid.

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was purified by reverse-phase semi-prep HPLC
  3. washeluting with a MeCN—H2O gradient

出典と根拠

ORDレコード
ord-49bd0cea88484ce482fece0a6ccef0ea
出典データセット
uspto-grants-2009_08
特許番号
US07576238B2

反応ノート

読み込み中…