Hydrazine hydrate (1:1) → 6-(4-Chlorophenyl)-4,5-Dihydropyridazin-3(2H)-One

HRID 2105

反応式

HRID 2105 の反応式
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10](O)=[O:11])=O)=[CH:4][CH:3]=1.O.[NH2:16][NH2:17]>C(O)C>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]2[CH2:8][CH2:9][C:10](=[O:11])[NH:16][N:17]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 776043-(4-Chlorobenzoyl)propionic acid

生成物 1

HCID 1209906-(4-Chlorophenyl)-4,5-Dihydropyridazin-3(2H)-One収率 81.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 3-(4-chlorobenzoyl)propionic acid (20 g) in absolute ethanol (200 ml) was added 5 g of hydrazine monohydrate. A thick solid was formed which dissolved after heating. The resulting solution was refluxed for 3 h, cooled and the solid formed filtered and dried to yield 16 g (80%) of 6-(4-chlorophenyl)-4,5-dihydropyridazinone.

後処理

  1. customA thick solid was formed which
  2. dissolutiondissolved
  3. temperatureafter heating
  4. temperatureThe resulting solution was refluxed for 3 h
  5. temperaturecooled
  6. customthe solid formed
  7. filtrationfiltered
  8. customdried

出典と根拠

ORDレコード
ord-3fcddcded91a4fbd88eca5020df9e5da
出典データセット
uspto-grants-1998_03
特許番号
US05728698

関連ノート

読み込み中…