Sodium Carbonate → HCID 87585486、化合物

HRID 2105233ノート

反応式

HRID 2105233 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([C:9]([OH:11])=[O:10])[N:3]=1.[NH2:12][C:13]1[CH:17]=[C:16]([CH3:18])[NH:15][N:14]=1.C(=O)([O-])[O-].[Na+:23].[Na+]>O>[Na+:23].[Cl:1][C:2]1[N:7]=[C:6]([NH:12][C:13]2[CH:17]=[C:16]([CH3:18])[NH:15][N:14]=2)[CH:5]=[C:4]([C:9]([O-:11])=[O:10])[N:3]=1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 2405302,6-dichloropyrimidine-4-carboxylic acid

生成物 1

HCID 87585486HCID 87585486、化合物収率 77%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2,4-dichloropyrimidin-6-yl carboxylic acid (Method 45) (528 mg, 2.73 mmol), 3-amino-5-methylpyrazole (279 mg, 2.87 mmol) and sodium carbonate (578 mg, 5.46 mmol) was heated in water (10 ml) at 50° C. for 18 hours. The mixture was allowed to cool and the product was collected by filtration, washed with water and dried to give the title compound (430 mg, 77%).

後処理

  1. temperatureto cool
  2. filtrationthe product was collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-3417b3c794e5417eb566f8875be6aa36
出典データセット
uspto-grants-2009_08
特許番号
US07579349B2

反応ノート

読み込み中…