Hydroxyamine hydrochloride → 1h-Imidazo[4,5-c][1,5]naphthyridine

HRID 2105454ノート

反応式

HRID 2105454 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[N:5]=[CH:4][C:3]=1[NH-:12].ClC1C2C(=CC=CC=2)[N:17]=[CH:16]C=1[NH-].Cl.NO>>[NH:17]1[C:2]2[C:11]3[N:10]=[CH:9][CH:8]=[CH:7][C:6]=3[N:5]=[CH:4][C:3]=2[N:12]=[CH:16]1

参加物

4

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 86625942HCID 86625942、化合物HCID 86625943HCID 86625943、化合物

生成物 1

HCID 1784207351h-Imidazo[4,5-c][1,5]naphthyridine

実験手順

In step (7) of Reaction Scheme II, an N-(4-chloro[1,5]naphthyridin-3-yl)amide or N-(4-chloroquinolin-3-yl)amide of Formula XXXII is reacted with a hydroxylamine hydrochloride of Formula R1ONH2.HCl and cyclized to provide a 1H-imidazo[4,5-c][1,5]naphthyridine or a 1H-imidazo[4,5-c]quinoline of Formula XXXIII. The reaction can be carried out using the method described in step (3) of Reaction Scheme I.

後処理

  1. customIn step (7) of Reaction Scheme II

出典と根拠

ORDレコード
ord-3d95590124734aa587f6d5bd3fa2a929
出典データセット
uspto-grants-2009_08
特許番号
US07579359B2

反応ノート

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